Initially lessons took place in a room in the Mercy Convent, but by 1894 the school was located in a four-storey house in Canal Street, Newry.

[1] In 2017 Arlene Foster the leader of the DUP visited the school at which she expressed being ‘uplifted’ after meeting pupils studying the Irish language.

In October 2019, the previous Technology facilities were demolished, and work began on a new ICT building which opened in April 2021.

[2] Our Lady's Grammar School has a long tradition of high performance in academics.

[3] In 2019 100% of its entrants received five or more GCSEs at grades A* to C, including the core subjects of English and Maths.