Our Lady of the Assassins (Spanish: La virgen de los sicarios) is a 2000 Spanish-language romantic crime drama film directed by Barbet Schroeder from a screenplay by Fernando Vallejo, based on his 1994 novel of the same title.

Fernando meets Alexis, a handsome gay youth, at a party of one of his old friends and immediately falls for him.

After several assassination attempts fail because of Alexis' skillful handling of his Beretta, he is finally killed by two boys on a motorcycle.

Seeing that the vicious cycle of atrocities in Medellín denies happiness, Fernando presumably commits suicide, if the last scene is taken to hint at that.

The film was shot with early high-definition video cameras (Sony HDW-700) in the year 2000.