The film stars Phoebe-Rae Taylor (in her screen debut), Rosemarie DeWitt, Luke Kirby, Judith Light, and Jennifer Aniston.

While she is unable to speak, her internal thoughts are rendered in the voice of actress Jennifer Aniston, due to her favorite TV show being Friends.

She has a younger sister named Penny and is constantly watched after by her parents Chuck and Diane, the former of whom believes Melody deserves a better education due to her very obvious intelligence.

Chuck and Diane meet Dr. Katherine Ray, a post-doctoral fellow with a Ph.D. in education, who offers the opportunity for Melody to be mainstreamed.

Chuck and Diane decide to apply for a Medi-Talker and Melody is able to speak with an electronic voice, which she happily uses to her heart's content.

Principal Antenucci is upset that Mr. Dimming's reputation is tarnished and Dr. Ray realizes that she has no concern for helping students like Melody.

In April 2015, it was reported that a film adaptation of Sharon Draper's novel Out of My Mind was in development at EveryWhere Studios and Gotham Group.

[2] In May 2022, it was reported that the film was in development for Disney+ by Disney Branded Television with Daniel Stiepleman as screenwriter, Amber Sealey as director and Phoebe-Rae Taylor set to star.

[3][4] In July 2022, Rosemarie DeWitt, Luke Kirby and Judith Light were cast in the leading roles alongside Taylor.

[12] Metacritic, which uses a weighted average, assigned the film a score of 73 out of 100, based on four critics, indicating "generally favorable" reviews.