Ove Høegh-Guldberg (born Guldberg; 1 September 1731 – 7 February 1808) was a Danish statesman, historian, and de facto prime minister of Denmark during the reign of the mentally unstable King Christian VII.

With the support of his maternal uncle Dines Guldberg, a priest in Gylling, he was educated as a theologian; he earned a theology degree in 1753.

In 1764 he was connected to Queen Juliana Maria as the house teacher of her son, Hereditary Prince Frederick, and in 1771 he became the latter's cabinet secretary.

In his new position, his national and conservative views influenced the prince, and the appointment launched Guldberg's future political career.

Being a conservative and devoted monarchist, he made common cause with the opposition against the rule of Johann Friedrich Struensee (1737–1772), regarding him a revolutionary and usurper.

Like Struensee, he mostly governed through direct cabinet orders, relying upon his influence on the royal guardians of the mentally ill Christian VII.

The deaths and removals of some of his government colleagues including Heinrich Carl von Schimmelmann (1724–1782) and Andreas Peter Bernstorff (1735–1797) enlarged his field of activity, but also made him more vulnerable to critics.