OverClocked ReMix was founded by David W. Lloyd, using the screen name djpretzel, as a video game music hosting website on December 11, 1999.

[1] At the time, there was a mixing scene that focused only on Commodore 64 music, with an electronica emphasis, but I love arranging, and I wanted an outlet where I could hone my skills while encouraging others to branch out and do the same.

[7][5] Originally coded in basic HTML and sporting an orange color scheme, and located at remix.overclocked.org, a subdomain of Lloyd's webcomic, the site underwent several visual redesigns before moving to www.ocremix.org in July 2003 and its present design in 2004.

[13] ReMixes are added to the site after being submitted by their creators and passed by a panel of judges based on standards and guidelines encouraging arrangement creativity and high production quality.

Other barriers to inclusion include stolen or unoriginal recordings, cover versions that change the performance but not the music itself, arrangements which differ so far from the source material as to be unrecognizable, and obvious sub-par execution.

[17] In 2008, the musicians of OverClocked ReMix were chosen to handle the Super Street Fighter II Turbo HD Remix soundtrack after Capcom U.S.A. associate producer Rey Jimenez heard the site's 2006 Super Street Fighter II Turbo tribute album Blood on the Asphalt.

[21] Capcom's then-Vice-President of Strategic Planning & Business Development, Christian Svensson, described the soundtrack as "impactful" and claimed in an interview that in demos of the game the remixed music was praised before any other aspect.

[29] In July 2015, the label published its first officially licensed remix, an arrangement of "Song of the Ancients" from Nier for streaming or purchase.

[37] In April 2008, Lloyd and Oji joined Six Apart's Anil Dash, MetaFilter's Matt Haughey, Reddit's Alexis Ohanian and Fark's Drew Curtis for a panel discussion on virtual communities at Internet meme convention, ROFLCon, co-sponsored by Harvard University and the Massachusetts Institute of Technology.

"[3] Several professional video game composers have positively commented about OC ReMix, such as Tommy Tallarico, Jeremy Soule, George "The Fat Man" Sanger, Hiroki Kikuta, Alexander Brandon, Barry Leitch, Nicholas Varley, and David Wise.

[3][40] OverClocked ReMix has also been praised for its work by non-composer industry figures including Doom lead designer John Romero and Contra 4 associate producer Tomm Hulett, who stated he hoped the game's music, scored by Jake "virt" Kaufman, would be arranged for OC ReMix in the future.

[45][46] In March 2010, OC ReMix released its Donkey Kong Country 2 ReMix album, Serious Monkey Business, featuring a closing track performed by the game's original composer, David Wise, alongside Grant Kirkhope and Robin Beanland, three composers with ties to Rare's Donkey Kong Country/Land franchise.

[47] Several amateur OC ReMix submitters and community members have transitioned into professional video game composition careers.

These include Dain "Beatdrop" Olsen (Dance Dance Revolution SuperNOVA 2),[48] Jillian "pixietricks" Aversa (Civilization IV: Beyond the Sword),[49] Zircon (Monkey Island 2 Special Edition: LeChuck's Revenge),[1] Christopher "Mazedude" Getman (The 7th Guest: Infection),[1] Jimmy "Big Giant Circles" Hinson (Mass Effect 2),[1] Jake "virt" Kaufman (Shovel Knight),[1] and Danny Baranowsky (Super Meat Boy).