[2] Its boundary includes almost all of Oxford, the University census-designated place, and some unincorporated areas.

In 2014, Oxford High School relocated and moved into a new $30 million building at 101 Charger Loop, due to the increasing number of students.

[6] The Oxford Chargers have won the Mississippi High School Athletic Association's All Sports Award 4A or 5A several years, fulfilling a commitment to being a first-class athletic program.

[7] Sports programs at Oxford High School include baseball, basketball, bowling, cheerleading, cross country, dance, fastpitch softball, football, golf, powerlifting, slowpitch softball, soccer, swimming, tennis, track and field, volleyball, and wrestling.

On December 7, 2019, the Oxford High School varsity football team completed a post-halftime comeback to win its first state title against Oak Grove, winning 31-21.