The community is located along the eastern shore of Oxford Lake at the mouth of Hayes River, 950 kilometres (590 mi) north of Winnipeg.

Oxford House was established in 1798 as a Hudson's Bay Company fur trading post on the fur trade route between York Factory on the Hudson Bay and Norway House some 30 km (19 mi) north of Lake Winnipeg.

[6] The two videos received attention from outside the community for the insight they offer into the problems facing youth living on remote reserves.

[7] Oxford House 24 Indian reservation had a population of 1,864 in 2011 living in 335 dwellings on a land area of 51.01 square km.

[8] Oxford House has a high school, elementary school, a pre-school (Head Start) an arena, a Northern Store with a Tim Hortons, a nursing station, a Royal Canadian Mounted Police detachment, the University College of the North Centre, an airport, a motel (Triple B), water treatment plant, band office, care home, medivac operation/emergency, youth building, a radio station, and a conservation office.