Oxon Creek is a stream on the Potomac River which feeds a cove that straddles the border between Washington, D.C., and Prince George's County, Maryland just north of Interstate 495 (Capital Beltway) at Woodrow Wilson Bridge.

[4] It starts just inside the boundary of D.C. and then runs 1.5 miles (2.4 km) to the south and west into Maryland to empty into the Potomac at Goose Island (a sand bar often under water) across from the city of Alexandria, Virginia.

The unusual spelling is either historical or a reference to Oxfordshire, England, though it was usually labelled as Oxen Creek on maps prior to 1898.

Following Hurricane Connie in 1955, the U.S. Army Corps of Engineers began planning a flood control project along Oxon Creek that realigned the channel, dredged the creek to 100 feet wide, and constructed a 3-foot concrete drop structure just upstream from the Forest Heights Tributary.

[14] In 2011, the section within the District was rebuilt as part of the project to create a new police evidence warehouse and, in the same year, the bridge connecting the Oxon Creek Trail and the Hiker-Biker path was constructed.