The roads ran from St. Louis, Missouri, to El Paso, Texas, and Santa Fe, New Mexico, over a series of routes.

In Oklahoma, portions of the section-line roads between Anadarko and Hobart are still referred to as "The Old Ozark Trail."

[3][4] They erected large obelisks marking the various roads and indicated distances to various towns and communities.

Twenty-one were constructed and of those only 7 still remain in existence, at Stroud, Oklahoma, Farwell, Dimmitt, Wellington, and Tulia, Texas.

The Ozark Trail ran through southwest Missouri and across Oklahoma, the Texas panhandle, and on into New Mexico.