They are known both for their vocal activist viewpoints and incorporating a wide array of musical styles – including salsa, jazz, funk, reggae, hip hop, and others.

[6] In a 2007 NPR interview, band members Jiro Yamaguchi and Ulises Bella describe Ozomatli: You drive down Sunset Boulevard and turn off your stereo and roll down your windows and all the music that comes out of each and every different car, whether it's salsa, cumbia, merengue, or Hip Hop, funk or whatever, it's that crazy blend that's going on between that cacophony of sound is Ozomatli, y'know?

By the album's release, the band had experienced several member changes: drummer William Marrufo had been replaced by Andy Mendoza, and MC Chali 2na, turntablist Cut Chemist, and saxophone player Jose Espinoza had all left.

In 2003, Ozomatli released a six-song EP through Concord Records, featuring a collaboration with the Kumbia Kings on "Mi Gente".

[12] In addition to Kanetic Source and DJ Spinobi, the album also featured new members Sheffer Bruton on trombone and Mario Calire on drums.

The resulting 10-man lineup: the core of Sierra, Pacheco, Bella, Abers, Porée and Yamaguichi joined by Bruton, Calire, MC Jabu and Dj Spinobi would last for the next few years.

In 2006, Ozomatli were invited by the U.S. State Department to serve as official Cultural Ambassadors on a series of government-sponsored international tours.

The band has since traveled to Asia, Africa, South America, the Middle East, Tunisia, India, Jordan, Nepal, Myanmar, Vietnam, Thailand, and China.

The album includes songs such as "After Party", which pays homage to old-school Chicano R&B, "When I Close My Eyes", which nods back to Fishbone and Oingo Boingo, "La Segunda Mano", which features the vocals of Quetzal's Martha Gonzales blending son jarocho with hip-hop, "City of Angels", which celebrates the city of Los Angeles, and "Temperatura", which was inspired by the May 2006 pro-immigration marches.

In early 2008, the group did a song for the Los Angeles Dodgers called "Can't Stop the Blue", their first recording with Tre Hardson.

Shortly thereafter, Sheffer Bruton and Tre Hardson were no longer seen playing with the group, and Mario Calire appeared back on the drumseat.

In 2010, Ozomatli released their fifth full-length album, "Fire Away", which was recorded by a stripped-down lineup, featuring the six constant members plus Carire on drums.

While the band's sound remained an eclectic mix, there was a noticeable drop in the influence of Latin musics, and not many lyrics in Spanish.

The album also had fewer overtly political songs, although the track 'Gay Vatos in Love' made a clear statement of support for LGBT rights.

[26] In this period of time, the band focused on Ozomatli Presents Ozokidz, a special family-friendly set geared towards performing for children and adults alike.

In 2021, Ozomatli released a cover of Ramon Ayala's "La Rama Del Mezquite", featuring Cherine Anderson.

[citation needed] Ozomatli create music to: give voice to and reveal the culture and lives of Latinos;[29] fight for workers' rights;[30] and promote a global unity within both the city and the world.