Pánuco (Spanish: [ˈpanuko] ⓘ) is a locality in the Mexican state of Zacatecas.

Pánuco was founded on 1 November 1548 by explorers Diego de Ibarra, Francisco de Ibarra, and Cristóbal de Oñate.

[1] It became the seat of the eponymous municipality upon its foundation in 1824.

[2] In the 2020 Mexican Census, Pánuco recorded a population of 1,177 inhabitants living in 434 households.

This article about a location in the Mexican state of Zacatecas is a stub.