[1] The Vranjska Banja spa plays a part in this region with its multi-medicinal thermal mineral waters.

The district encompasses the municipalities of: The ancient Paeonian tribe of the Agrianians ruled the region in antiquity.

Also famous are the ancient Turkish public baths from the 16th century and the Pasha's House from 1765, in which a grammar school was opened in 1882.

In addition, reports emerged in 2006 that the municipality of Trgovište had threatened to secede itself to North Macedonia, which was noteworthy, since it had (and still has) a majority Serb population.

[1] Based on the census results from 2022, the Pčinja District has a Christian Orthodox majority (60.4%) and a substantial Muslim minority (31%).