Ethnikos Neo Keramidi made its first appearance in a national category during the 2020–21 season, securing a 3rd-place finish in its group with 25 points.

The following season proved challenging, with the team barely avoiding relegation by a single point.

In subsequent seasons, Ethnikos Neo Keramidi established itself as a formidable force in the Gamma Ethniki, boasting a strong squad.

In February 2023, the club appointed Vangelis Moras, a former international footballer and coach of Apollon Larissa and P.O.

Ethnikos Neo Keramidi won their Gamma Ethniki group and achieved automatic promotion to Super League Greece 2, the second division of Greek football.