The team has no geographical base, instead being made up of some of the best players from across Pakistan.

[1] The side was formed ahead of the 2021–22 Pakistan Women's One Day Cup, adding to the previously three-team competition as a reflection of the growing number of female cricketers in Pakistan.

[2][3] PCB Strikers were formed in 2021 to compete in the Pakistan Women's One Day Cup, expanding the competition from three teams to four, to allow greater opportunities for players to participate.

[2] In their first season, they were captained by Kainat Imtiaz and coached by Arshad Khan.

[4] In the group stage, they won two matches, both against PCB Dynamites, to finish third.