1PDG, 3MJG, 4HQU, 4HQX, 4QCI515518591ENSG00000100311ENSMUSG00000000489P01127P31240NM_033016NM_002608NM_011057NP_002599NP_148937NP_035187Platelet-derived growth factor subunit B is a protein that in humans is encoded by the PDGFB gene.

[5][6] The protein encoded by this gene is a member of the platelet-derived growth factor family.

The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines.

This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha (PDGFA) polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds.

This fusion gene greatly overproduces PDGFB and is considered responsible for causing the development and/or progression of three closely related fibroblastic and myofibroblastic tumors of the skin: giant cell fibroblastoma, dermatofibrosarcoma protuberans, and dermatofibrosarcoma protuberans, sarcomatous.