In their inaugural 2011–12 season in A Group after promotion, Ludogorets won the double by capturing the league championship and the Bulgarian Cup.

Subsequently, the club made a significant continental impact in the 2013–14 UEFA Europa League when they reached the Round of 16 in only their second European run.

Ludogorets are also only the second Bulgarian team after Levski Sofia to enter the group stage of the UEFA Champions League, a feat which they achieved in the following 2014–15 season.

During that same campaign, they became the first Bulgarian team to score points in the modern Champions League group stage following a 1–0 win over Basel in Sofia.

[8] In September 2010 the club was purchased by a Bulgarian pharmaceutical entrepreneur Kiril Domuschiev, with the clear intention of bringing Ludogorets to the top division.

This happened in May 2011 with Ivaylo Petev as a Head Coach when the team promoted to top division for the first time in the club's history.

On the final day of the season, Ludogorets had to beat the already relegated team of Montana and hope that Slavia Sofia would prevent Levski from winning their match.

In the last minutes of the Levski–Slavia match, Levski conceived an own goal which subsequently led to a 1:1 draw, allowing Ludogorets to win their second championship title in dramatic fashion again.

For the second time in the Bulgarian's football history the team entered the Champions League groups with Georgi Dermendzhiev as a Head Coach.

After a long hard season and a change in head coach in the middle of the season, with the return of former manager Ivaylo Petev back at helm, Ludogorets managed to achieve a domestic double (their 3rd similar feat since being promoted to the Bulgarian First League) by winning firstly the Bulgarian Cup by beating CSKA 1948 3:1 in the final, and eventually also winning the Bulgarian League once again for a record twelfth time by one point over CSKA Sofia by beating Cherno More Varna away from home 1:0 on the last day/match of the domestic championship season.

Georgi Dermendzhiev returned as Head Coach of Ludogorets Razgrad after the sacking of Ivaylo Petev back in October 2023.

At the end of the 2023-24 campaign, the club managed to once again retain their domestic championship title for a record thirteenth time in row by beating PFC CSKA Sofia 3–1 in Razgrad to make it mathematically impossible for anyone to catch them in the race.

After winning the 2011–12 Bulgarian title, Ludogorets entered the second qualifying round of the UEFA Champions League for the 2012–13 season, but were eliminated 3:4 on aggregate with a last minute away goal by Dinamo Zagreb.

Goalkeeper Vladislav Stoyanov was dismissed for a second yellow card in the last minute of extra time in the second leg, when Ludogorets had used all their substitutes.

[18] Ludogorets made their debut in the 2014–15 Champions League group phase on 16 September 2014, grabbing a 1:1 equalizer away against Liverpool in the 90th minute scored by Dani Abalo, but in an eventual 1:2 loss,[19] as the newly signed goalkeeper Milan Borjan gave away a penalty with a foul on Javier Manquillo, which Steven Gerrard converted to give Liverpool the victory.

[19] Ludogorets made their home debut in the 2014–15 Champions League group phase on 1 October 2014, scoring a stunning goal in the sixth minute through' attacking midfielder Marcelinho against Real Madrid, but in an eventual 1:2 loss.

[20] In this match, Cristiano Ronaldo took two penalties – the first was saved by goalkeeper Vladislav Stoyanov, while the second was scored for a 1:1 equalizer.

With Georgi Dermendzhiev returning at the helm of the squad, during the 2016–17 Champions League, Ludogorets won the qualifiers against Mladost Podgorica and Red Star Belgrade respectively, followed by a success in the play-off against Viktoria Plzeň.

In the group stage, Ludogorets achieved two draws against Basel and one against Paris Saint-Germain, which were enough to secure them the third place and a transfer to the knockout phase of the 2016–17 UEFA Europa League.

In the 2017–18 season they finished second in the group behind Braga, eliminating İstanbul Başakşehir and 1899 Hoffenheim, before losing in both matches to Milan in the round of 32.

[23][24] They lost twice to Espanyol, 1–0 at home and 6–0 away, but finished second, following two 1–1 draws against both CSKA and Ferencváros, eventually securing a place in the knockout stage.

[25] Ludogorets earned their record-breaking 9th Bulgarian Premier League Title during their 75th Anniversary celebration on 8 July 2020 after their win 3:0 vs Levski Sofia.

[30] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.