The PFL 1 mixed martial arts event for the 2024 season of the Professional Fighters League was held on April 4, 2024, at the Boeing Center at Tech Port in San Antonio, Texas, United States.

This marked the first regular-season event of the tournament and included fights in the Women's Flyweight and Heavyweight divisions.

[4] On March 26, changes to the fight lineup saw 2021 PFL heavyweight winner Bruno Cappelozza replaced by former WSOF Heavyweight Champion Blagoy Ivanov against Sergei Bilostenniy, and a PFL women's flyweight alternate bout between Kaytlin Neil and Sumiko Inaba removed from the card.

[4] Originally, Daniel James was expected to face Tyrell Fortune in a rematch at the event.

If a fighter misses weight, the opponent (should they comply with weight limits) will receive 3 points due to a walkover victory, regardless of winning or losing the bout; if the non-offending fighter subsequently wins with a stoppage, all bonus points will be awarded.