PNC Tower is a skyscraper in Downtown Louisville, Kentucky, and located at 101 South Fifth Street.

PNC Tower was the tallest building in the state of Kentucky from 1972 until 400 West Market was completed in 1993.

The tower is constructed of steel columns on concrete piles of caissons with an anodized aluminum and glass curtain wall.

In February 2010, the National City logos on east and west sides of the tower were replaced with PNC Bank logos, due to PNC's takeover of National City Bank.

[3] Tenants include Humana Inc.,[4] PNC Bank, the Louisville branch of the Federal Reserve Bank of St. Louis, Bingham Greenebaum Doll PLLC, Dinsmore & Shohl LLP and Fultz Maddox Dickens PLC.