Puerto Rico Highway 165 (PR-165) is the road that goes from Naranjito to Guaynabo.

[4] This highway begins at its junction with PR-164 (road from Naranjito to Corozal) and ends at San Patricio (near Caparra).

In Dorado the road is one lane in each direction and parallel to the northern coast of Puerto Rico.

In Cataño it is a short highway which begins at the Bacardi Distillery and ends at the Federal Prison.

Puerto Rico Highway 165R (Spanish: Carretera Ramal 165, abbreviated Ramal PR-165 or PR-165R) is the road that goes to downtown Toa Alta, Puerto Rico.