[10] The N-terminal of mPTGES2 is attached to the lipid membrane and the two hydrophobic pockets connected to form a V shape are located in the bottom of a large cavity for IMN binding.

The PTGE2 protein encoded by the gene is a 33-kDa membrane-associated [11] prostaglandin E synthase that is thought to be targeted to the Golgi apparatus as well as the mitochondrion within the cell.

[8] The excess production of prostaglandin E 2 is known to contribute to inflammatory diseases which includes rheumatoid arthritis, atherosclerosis, and cancer.

[16][17] As such, pharmacological inhibition of prostaglandin E 2 production by synthetic minor prenylated chalcones and flavonoids has potential therapeutic viability.

[19] This article incorporates text from the United States National Library of Medicine, which is in the public domain.