His work caught the eye of the Far Eastern University founder, Dr. Nicanor B. Reyes, Sr., who was looking to build a school campus that was modern in style.

[5] Antonio also designed the White Cross Orphanage (1938) along Santolan Road in San Juan City, and the Manila Polo Club (1950) in Makati.

[2] He was cited for taking Philippine architecture into a new direction, with "clean lines, plain surfaces, and bold rectangular masses.

In order to highlight natural light and also avoid rain seepage, he utilized sunscreens, slanted windows and other devices.

His eldest son, Architect Pablo Reyes Antonio Jr., restored some of his art deco buildings in the FEU campus.