[4][5] From July 9 to 27, 2012, Telemundo aired one-hour episodes of Pablo Escobar weeknights at 10 pm/9c, replacing Decisiones Extremas.

[6][7] From July 30, 2012, to January 24, 2013, Telemundo aired half-hour episodes of Pablo Escobar and El Rostro de la Venganza weeknights, both sharing the 10 pm time slot.

[10] The series begins and ends with his dramatic last moments before being shot to death by agents of the National Police of Colombia, while escaping from a relative's home, and later flashing back to his childhood in Aburra Valley, Colombia, where Pablo is teased by his cousin, Gonzalo, and older brother, Peluche, on a footbridge crossing a creek, eventually rescued by his mother, who scolds Pablo for crying.

As he and Gonzalo became older, they began their lives of organised crime, becoming bodyguards to a well known smuggler and eventually his partners, after successfully standing off with police in what would become Escobar's trademark "Plata o Plomo" approach to dealing with law enforcement – "accept our bribe or prepare for a shootout with us."

"[16] Telemundo's July 9 broadcast of Pablo Escobar: El Patrón del Mal averaged nearly 2.2 million viewers.