Pachypanthera is an extinct genus of pantherine felid (big cat) that was recovered from the Late Miocene-aged Khorat sand pits in northeastern Thailand.

The holotype (CUF-KR-1) comprises the left half of the mandible with the incisor and canine alveoli, the third and fourth premolars, and the first molar, missing its crown.

[1] The robustness of the jaws and the teeth suggests Pachypanthera had a durophagous diet, and so it was likely adapted to process hard animal material, like shells and bones.

While there are no post-cranial remains of this big cat, weight estimates extrapolated from the size of the teeth suggest the animal weighed 142 kilograms (313 lb).

[1] The fauna of the sand pits overlap with fossil mammals found in the lower Dhok Pathan zone in the Siwaliks and are thus considered to be of similar age.