The museum also owns and manages a railroad depot in La Mesa, California.

Since 1986, the Pacific Southwest Railway Museum operates all-volunteer train excursions from the restored 1916 Depot in Campo, in the Mountain Empire area of southeastern San Diego County, California.

The museum is also home to the Southwest Railway Library, which opened in Campo in July 2014.

It is the oldest building in town and is the sole surviving San Diego and Cuyamaca Railway station.

[12] The museum's renovation of the depot won an award from San Diego's historic preservation society, Save Our Heritage Organization.