[4] In the north of its range, wet winters often promote a brown to black leaf discoloration due to fungal infections;[6][7] the stain lasts until the leaves naturally detach at the end of their lifespan.

In spring, the tree bears sprays of small white to pink bell-like flowers,[4] and in autumn, red berries.

[9] Its species name was given it in honor of the Scottish naturalist Archibald Menzies, who noted it during George Vancouver's voyage of exploration.

[4] Many mammal and bird species feed off the berries,[14] including juncos, American robins, cedar waxwings, band-tailed pigeons, varied thrushes, quail, mule deer, raccoons, ring-tailed cats, and bears.

[16] Mature leaves are almost always ignored by browsing animals, but young leafy sprouts are eaten by ungulates and the dusky-footed woodrat.

[citation needed] This may be due to the susceptibility of the tree to heart rot, which makes it desirable for cavity-nesting birds.

Pacific Madrona also provides cover for big game and small mammals, and perching sites for a variety of bird species.

Until about 1970, this phenomenon was not widely recognized on the west coast; thereafter, many local governments have addressed this issue by stringent restrictions on grading and drainage alterations when A. menziesii trees are present.

[citation needed] Invasive species such as Scotch broom and gorse are a threat to the Pacific madrona as they can invade natural areas and outcompete young saplings for space, light, nutrients, and water.

The tree was located within the Joshua Creek Canyon Ecological Reserve on the Big Sur Coast of California.

The site should be sunny (south- or west-facing slopes are best), well drained, and lime-free (although occasionally a seedling will establish itself on a shell midden).

[citation needed] This plant has gained the Royal Horticultural Society's Award of Garden Merit.

[16] Native Americans also use the berries to make necklaces and other decorations, and as bait for fishing (as did the Karuk people to catch steelhead).

[4] The wood is durable and has a warm color after finishing, so it has become more popular as a flooring material, especially in the Pacific Northwest.