The Packwood House-American Hotel, also known as the Packwood House Museum, is historic inn and tavern that is located in Lewisburg, Union County, Pennsylvania, United States.

Located on Market Street in the Lewisburg Historic District, it was listed on the National Register of Historic Places in 1978.

Built circa 1813 and expanded circa 1866, this historic structure is a three-story, log and frame building with a gable roof.

It has a two-story, pent roof, rear addition.

[2] It was listed on the National Register of Historic Places in 1978.