Born in Seville, León began his career in television comedy roles in Andalusian regional productions.

Following appearances in sketch show Homo Zapping [es], he became popular in Spain for his performance from 2005 to 2014 in sitcom Aída, portraying Luisma, a good-natured rehabilitated drug addict.

[1][2] In addition to his acting career, he has also pursued an activity as a filmmaker and show creator, starting with his debut feature Carmina or Blow Up (2012), for which he was nominated to the Goya Award for Best New Director.

León's first roles were in comedy television, on Mariquilla Ríe Perlas and Castillos en el aire in 1999.

He moved to Madrid in 2003 to continue his career, where his first big job was impersonating personalities on Homo Zapping, where he was noticed for popular imitations of women like Anne Igartiburu and Raquel Revuelta.

[8] Fernández also notes how both León and Almodóvar are influenced by the women in their lives, that they both often work with a sibling, and celebrate their mothers in their films.

[6] In 2019, profiling the actor, Dann Dulin wrote that León's "persona and popularity are akin to a James Franco or Jake Gyllenhaal".

He has several friends living with the disease and has worked with organisations including Fundación Triángulo, Apoyo Positivo, StopSIDA, and the Fight Against AIDS Foundation since at least 2009, which largely offer support to the LGBT+ community in Spain, as well as fundraising for the work of eminent HIV researcher Bonaventura Clotet.