The brick-built street-level entrance building featured a balustrade along the edge of the roof decoratively topped with urns.

Fowler's building was demolished and reconstructed to a design by the MR's architect Charles W Clark in 1914 with a cladding of white faïence blocks.

On 30 October 1883, a bomb planted by Fenians campaigning for an independent Irish Republic exploded on a train near the station.

[16] The deep-level station was opened by the Baker Street and Waterloo Railway (BS&WR, later the Bakerloo line) on 1 December 1913 as the temporary terminus of its extension from Edgware Road.

[10] To enable the BS&WR to continue its route to the north-west of Paddington, the station platforms were constructed in a tight curve.

[18] Construction work continued beyond the station to extend the line further to Queen's Park where it met the mainline tracks of the London and North Western Railway.

Following their successful introduction at Earl's Court in 1911, the station was the first on the line to be designed to use escalators instead of lifts.

[18] The ticket hall and platforms are decorated with tiling designs by David Hamilton installed during a £6 million refurbishment of the station between 1984 and 1987 incorporating elements of technical drawings by Marc Isambard Brunel and other engineers.

[13][19][20] In December 2016, Westminster City Council approved proposals to construct a new mixed-use development called Paddington Square on a site adjacent to the mainline station.

[24] To achieve this, the Bakerloo line station was closed for 5 months in 2016 to allow for construction to take place, as well as the replacement of escalators.

[31] The station is served by London Buses day and night via multiple routes running on Praed Street.