The famous character artist Radhakrishan made his acting debut in the film as a villain.

[5] The film starred Mazhar Khan, Gajanan Jagirdar, Anees Khatoon, Radha Kishan, Lajwanti, Sumitra, Gopal and Balak Ram.

[4] With his trio of social films and especially Padosi, Shantaram has been cited by author Bajaj as the third best pre-1960 director in the top ten rating, following P. C. Barua for Devdas (1935) and Homi Wadia for Miss Frontier Mail (1936), followed by Mehboob Khan for Mother India (1957).

Pandit (Mazhar Khan) a Hindu, and Mirza (Gajanan Jagirdar) a Muslim, are two old friends who function as the village elders and look out for each other's families.

The Marathi cast included Gajanan Jagirdar, Keshavrao Date, Chandrakant, Jayashree and Master Chhotu.

The lyrics were written by Pandit Sudarshan and the singers were Krishnarao, Anees Khatoon, Balwant Singh, Balakram, Gopal and Mulia.