Padre Aldamiz International Airport is near some of Peru's noted ecological areas, such as the national jungle reserve of Tambopata-Candamo.

Western doctors often warn that airport authorities require travelers to carry documentation informing about yellow fever vaccination because of its rainforest location.

AeroPerú ceased operations in 1999, and, subsequently, other airlines have entered the Lima to Puerto Maldonado air route.

Nuevo Continente made an attempt in 2004, but that airline suspended operations amid allegations of drug trafficking by their owners.

The Peruvian Air Force flies Boeing 707 jets to Padre Aldamiz International Airport, to carry civilian cargo operations.