The Paederinae are a subfamily of the Staphylinidae, rove beetles.

[1][2] As of 2024[update], three tribes are accepted within this subfamily: Lathrobiini, Paederini, and Pinophilini.

[citation needed] Three of the genera of a subtribe of the Paederini are associated with a skin irritation called Paederus dermatitis, due to a potent vesicant in their haemolymph.

[4] This irritant, pederin, is highly toxic, more potent than cobra venom.

[5] Thirty-six genera and 436 species are found in North America, generally in damp places, under logs, in caves and ant nests, in litter, or on foliage.