[citation needed] On 13 September 2023, during the first meeting of the 63rd Thai Cabinet, Prime Minister Srettha Thavisin ordered the establishment of the National Soft Power Strategy Committee and appointed Paetongtarn as the Deputy Chairperson.

[16][17] Her nomination was approved by the House of Representatives on 16 August after no alternatives were named by the other parties in the ruling coalition,[18][19] making her the youngest person and the second woman to become Prime Minister of Thailand.

These included comprehensive debt restructuring, measures to support Thai entrepreneurs, reductions in energy and utility costs, and efforts to integrate the informal and underground economies into the tax system.

Additional priorities included economic stimulus through digital wallets, modernization of the agricultural sector, tourism promotion, anti-narcotics initiatives, crime prevention, and enhancements to social welfare, particularly for vulnerable groups, stateless individuals, and ethnic minorities.

[24] Following the policy announcement, on 13 September 2024, Paetongtarn and relevant Cabinet members visited Mae Sai district, Chiang Rai, to assess the flood situation in northern Thailand.

[25] In January 2025, Paetongtarn revealed that she had nearly been victimized by a scam utilizing a message in a voice sounding identical to another world leader whom she did not disclose in which the caller was asking for donations.

[26] In February 2025, Paethongtarn Shinawatra ordered the suspension of electricity, internet, and fuel supplies to five border areas in Myanmar as part of a multinational effort to dismantle transnational scams and human trafficking networks operating in the region.

The decision was made in response to public demand for action against online scams and was agreed upon by Thailand's National Security Council and other government agencies.

[27] During her first official trip to China from 5-8 February 2025, Paetongtarn Shinawatra emphasized strengthening Thailand-China ties in sectors like electric vehicles, semiconductors, and data centers.

[37] Alpine Golf Course, located in Khlong Luang District, Pathum Thani Province, was originally owned by Nueam Chamnarnchatsakda, who donated the land to Wat Thammikaram Worawihan [th] in 1969.

However, questions arose over her admission, as her cumulative high school GPA was reportedly below 2.75 and her second-round entrance exam scores were significantly higher than her first-round results.

However, he ordered disciplinary action and reprimands against Professor Police Colonel Dr. Woradej Chandrasorn, Secretary-General of the Office of the Higher Education Commission, and Sasithorn Ahingsako, Director of the Central Testing Bureau, for their roles in opening exam envelopes prematurely.

[49] She is married to Pitaka Suksawat, a Thai businessman who is the Deputy Chief Investment Officer of Rende Development Co., Ltd., and a board member of the Thaicom Foundation.