Paganico Sabino is a comune (municipality) in the Province of Rieti in the Italian region of Latium, located about 50 kilometres (31 mi) northeast of Rome and about 25 kilometres (16 mi) southeast of Rieti.

Paganico Sabino borders the following municipalities: Ascrea, Collegiove, Marcetelli, Pozzaglia Sabina, Varco Sabino.

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