The Pakistan-Uzbekistan Joint Ministerial Commission (JMC) is held on a regular basis.

Relations between the two states were established when the republic of Uzbekistan became independent following the collapse of the USSR in 1991.

[3] However, relations improved after the fall of the Taliban,[4] as well as the death of Uzbek President Islam Karimov and subsequent deepening of Uzbek outreach to regional countries under his successor, Shavkat Mirziyoyev.

[8] The first direct flights between the countries began in 2018 between Tashkent and Lahore, launched by Uzbekistan Airways, and are expected to further increase trade between the two countries The Uzbek population in Pakistan numbers roughly 70,000 and consists of a small number of Uzbek immigrants from Uzbekistan and a much larger number of Uzbek refugees from northern Afghanistan (around 2.3% of Afghans in Pakistan are Uzbeks).

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