[13] Pakistan won the first ODI by three wickets,[14] with South Africa winning the second match by seventeen runs to level the series.

[20] Ahead of the tour, Saud Shakeel was ruled out of Pakistan's ODI squad due to an injury, with Asif Ali named as his replacement.

[25] Quinton de Kock, David Miller, Kagiso Rabada, Lungi Ngidi and Anrich Nortje were only available for the first two ODIs, before leaving South Africa's squad to play in the 2021 Indian Premier League.

[29] Dwaine Pretorius was also ruled out due to rib injury, and Reeza Hendricks opted out of the series for personal reasons.

[30] Aiden Markram, Andile Phehlukwayo, Daryn Dupavillon and Wiaan Mulder were added to South Africa's T20I squad.