The official inauguration, in the presence of King Alfonso XIII, Queen Victoria Eugenie of Battenberg, the infantas and other authorities, took place on 5 October 1929.

After remaining closed and unoccupied during the Second Republic and the Civil War, in 1952, the palace served as accommodation for cardinal Angelo Dell'Acqua, Pontifical Legate, who came to Barcelona for the XXXV Eucharistic congress.

In 1957, Mayor Josep Maria de Porcioles i Colomer decided to convert the building into accommodation for distinguished visitors, including Prince Constantine of Greece, Richard Nixon, William Tubman, Habib Bourguiba, Cardinal Eugène Tisserant and Christian Pineau.

[2] From 1965 to 1970, the Barcelona City Council decided to remodel and expand the palace, and awarded the project to the local architects Joaquim Ros de Ramis, Antoni Lozoya and Ignasi Serra Goday.

The renovation also included the creation of a dome with paintings by Salvador Dalí that evoke culture and the city and another with a stained glass window by Carlos Muñoz de Pablos.

[4][2] During the 1960s, several paintings by contemporary local artists were added to its interiors, such as Martí Alsina, Casas, Josep de Togores or Vayreda, as well as furniture from the personal collection of Luis Plandiura.

The original gardens were designed by Jean-Claude Nicolas Forestier with the assistance of Spanish landscape architect Nicolás María Rubió Tudurí.

Due to the desire to transform the palace into a true royal residence, since the Palau Reial de Pedralbes was not to the future King Juan Carlos I pleasure, in the 1970s the gardens were enlarged.