The Ministry of Foreign Relations (Spanish: Ministerio de Relaciones Exteriores, MRREE) is the ministry of the Government of Uruguay that is responsible for planning, directing and executing the foreign policy and international relations of the Republic.

This government department is headquartered in the Santos Palace, in Barrio Centro, Montevideo.

The Minister of Foreign Relations is more commonly known as Canciller (Spanish for 'Chancellor').

It is commonly referred to in Uruguayan media and diplomatic jargon as the Palacio Santos, after the historical building which since 1955 has housed the ministry (originally the residence of President Máximo Santos in the late 19th century).

[1] This building is one of the major historic structures in the Uruguayan capital, and has been the subject of prominent documentary publicity.