Palatinate-Zweibrücken-Birkenfeld[a] was a state of the Holy Roman Empire based around Birkenfeld within the Upper Rhenish Circle.

Palatinate-Zweibrücken-Birkenfeld was created in 1569 in the partition of the County Palatine of Zweibrücken after the death of Wolfgang for his youngest son Charles I.

After Charles' death in 1600 his state was partitioned into itself and Palatinate-Birkenfeld-Bischweiler by his sons, with George William succeeding him in Birkenfeld.

Two years later he died, and with him the male line of the branch, so the state passed to Christian II of Palatinate-Birkenfeld-Bischweiler.

In 1731 Christian inherited the Duchy of Zweibrücken and its seat in the Imperial Diet, and renamed his territories to Palatinate-Birkenfeld-Zweibrücken.