The station was built in 1908 for the Atlantic Coast Line Railroad (ACL) and was constructed in the Richardsonian Romanesque style.

[2] In 1971, most passenger service in the United States was transferred to Amtrak, however Palatka had its stop discontinued.

[6] In November 2021, the US Department of Transportation awarded $1.5 billion in RAISE discretionary grants for infrastructure projects around the nation.

[7] One such grant awarded $8.2 million to fund the development of the A. Philip Randolph Regional Multimodal Transportation Hub.

The museum features a model train layout, historic documents, photographs, maps, signs and railroad artifacts.