Tenor and conductor Plácido Domingo has maintained a special relationship with the Palau since its founding and has established a young singers training program there.

Among them is Zubin Mehta, who leads an annual music and opera festival, the Festival del Mediterráneo, which began in 2007; the late Lorin Maazel, who became music director of the company before his death; and Plácido Domingo, who brought his Operalia competition to the Palau in October 2007,[7] and performs there regularly (Cyrano de Bergerac in 2007, Iphigénie en Tauride in 2008, Die Walküre in 2009, etc.).

Soloists included Plácido Domingo, Christopher Ventris, Vittorio Grigolo, Maria Guleghina, and Cristina Gallardo-Domâs.

The 2008-2009 Festival del Mediterrani included the complete Der Ring des Nibelungen cycle conducted by Zubin Mehta, again with Plácido Domingo.

[10] On 21 January 2015, Spanish police arrested the company's general director, Helga Schmidt, for alleged financial irregularities at the house.