On 13 luglio del 2006 it was added to the list of 42 palaces which now form the UNESCO World Heritage Site Genoa: Le Strade Nuove and the system of the Palazzi dei Rolli.

The Rolli di Genova - or, more precisely, the Rolli degli alloggiamenti pubblici di Genova (Italian for "Lists of the public lodgings of Genoa") were the official lists at the time of the Republic of Genoa of the private palaces and mansions, belonging to the most distinguished Genoese families, which - if chosen through a public lottery - were obliged to host on behalf of the Government the most notable visitors during their State visit to the Republic.

Later, these palaces hosted many famous visitors to Genoa during their Grand Tour, a cultural itinerary around Italy[1] Antonio Doria, cousin of the Genoese Admiral Andrea Doria, after his former residence was demolished to make way to the construction of the new walls, commissioned the palace to Bernardino Cantone and, later, to Giovan Battista Castello.

In 1624 the palace passed to the Spinola family, which expanded it to the East with a richly-decorated gallery by Andrea Ansaldo, demolished in the 19th century to open via Roma.

The main rooms were decorated by Giovanni and Luca Cambiaso with scenes from the Trojan War and battles between sea monsters.