Erected between 1619 and 1623, in an area characterised by strong residential expansion, the mansion expresses a traditional language of ostentatious pursuit of symmetry in plan and elevation.

Despite the narrowness of the space due to the building behind, the palace is not without a certain scenographic taste, proposing, with its courtyard in the shape of a triforium, the courtly solution of a 'royal entrance' culminating against the back wall in a small nymphaeum that has disappeared today, but is partly visible in the rubensiana.

[1] Around 1855, it was sold by the Lomellini family to the Patrone family,[2] who owned it until 1897, when the building was ceded by its last owner, Fausto Patrone, to the Genoa City Council, which, in order to widen the street section between Largo della Zecca and Piazza della Nunziata, demolished one of its corners, eliminating a sitting room and an adjoining lavatory on each floor.

The plugging of the courtyard loggia, with the insertion of two columns similar to those already existing and the creation of new vaulting (architecture) in 1923, was the choice of Antonio Orazio Quinzio, then director of the municipal museums, who also carried out the grotesque decoration of the reception staircase.

[3] An admired cycle of frescoes by Domenico Fiasella illustrating Stories of Ester can be seen inside the church:[4] the importance of expressive quality is flanked by that of a profound political allusion that the commissioner intended to manifest by choosing it among biblical themes.