Catherine de' Medici, Clement VII's niece, also lived here before she was married to Henry, son of King Francis I of France in 1533.

Cardinal Francesco Maria Del Monte, patron of the artist Caravaggio, lived there until his death in 1627.

After the extinction of the Medici in 1743, the palace was handed over to the House of Lorraine and, later, to Pope Benedict XIV, who made it the seat of the Papal Government.

In 1849, Pius IX moved here the Ministries of Finances and of the Public Debt, as well as the Papal Post Offices.

Some other Italian institutional buildings: Media related to Palazzo Madama (Rome) at Wikimedia Commons