During that time his cousin Luigi Gonzaga (later Saint Aloysius) also lived there, as did the poet Torquato Tasso from 1587 to 1590.

Its style is broadly based on Palazzo Farnese; the lower floors exemplifying the architecture of the late Renaissance found in Rome and throughout Lazio.

The corners of the irregular building are accentuated by quoining, while shallow pilasters divide the five bays from the first floor upwards.

[4] However, the architect was either not working in his usual style or it has been subsequently altered, for the uppermost floor appears of no more architectural merit than those added to many other palazzi during the eighteenth and nineteenth centuries.

The second fountain is on the external corner of the palace which tapers to the confluence of via dells Scrofa and piazza Nicosia.

However, it is not for his piety or noble connections that the cardinal is chiefly remembered, but for his friendship and patronage of the troubled poet Torquato Tasso and his support, against other family members, for his cousin Saint Aloysius Gonzaga.

Saint Aloysius stayed in the building from 20 November 1585 before renouncing his worldly possessions and rank and joining the Society of Jesus.

Passing through the hands of the Casate and Astalli o Staglia families, before being acquired by the Negroni and undergoing renovations and alteration.