The Palazzo Ruspoli is a Renaissance-style, 16th century aristocratic palace located on Via del Corso 418, where Corso intersects with Largo Carlo Goldoni and the Piazza di San Lorenzo in Lucina, in the Rione IV of Campo Marzio in central Rome, Italy.

He consolidated the long three-story facade along via de Corso and added a loggia along the inner courtyard, frescoed by Jacopo Zucchi and used to display the family's ancient sculpture collection.

Circa 1640, the architect Martino Longhi the Younger was commissioned to build the scenographic staircase leading to the courtyard.

In the 19th century, the palace hosted the famed Caffè Nuovo, and it was also home to the exiled Napoleon III.

Along the stairs were antique busts of emperors Hadrian and Claudius; Bacchus and Silen; Apollo; Mercury; a woman dressed as Hercules; and Aesclepius.