Palazzo Santa Sofia is a palace in Mdina, Malta, located in Villegaignon Street, across the square from the cathedral.

The ground floor of Palazzo Santa Sofia was built in the 13th century, and the date 1233 is inscribed on the moulding of one of its windows.

[4] Today, the palace is privately owned, and it is managed by a local heritage foundation Fondazzjoni Patrimonju Malti.

[2] Palazzo Santa Sofia originally had a single story, and was built around a central courtyard.

[6] The more recent upper floor is characterized by four ornate mullioned windows, and a one-tiered palline losanghe cornice is located at the roof level.