It was built by the architect Bernardo Spazio and then continued by Pietro Orsolino until the end of the work in 1558 for Pantaleo Spinola, who died in 1536 without ever living in the palace.

[2] The façade, with its very simple lines, is enlivened by the rhythm of the windows, the overhang of the balconies and especially the portal surmounted by two marble statues, allegories of Prudence and Vigilance.

The ground floor is richly frescoed with biblical episodes painted in the first decades of the Seventeenth century by Giovanni Carlone: Susanna and the Old Men, The Judgement of Solomon, The End of Assalon.

In the hall on the piano nobile, accessed by climbing an elegant staircase, the volta was frescoed at the end of the 17th century, with a mythological subject depicting The offering to Jupiter of the keys of the temple of Janus, with an allegorical meaning extolling peace, executed by the Genoese Domenico Piola and the Emilian Paolo Brozzi, a specialist in perspective quadratures.

Again Piola, a dominant artist in the second half of the 17th century in Genoa, is the author of the vault with The Sibyls show the Virgin Mary to Augustus, a Christian reinterpretation of pagan themes, surrounded by episodes depicting The Seasons.