On 13 luglio del 2006 it was added to the list of 42 palaces which now form the UNESCO World Heritage Site Genoa: Le Strade Nuove and the system of the Palazzi dei Rolli.

An etching of its façade is included in Peter Paul Rubens's 1622 book I Palazzi di Genova, printed in Antwerp in 1622.

Maddalena directed the Rococo refurbishment in the mid-18th century, and engaged Lorenzo De Ferrari, Giovanni Battista Natali and Sebastiano Galeotti to paint the quadratura and decoration.

Her grandson, Paolo Francesco Spinola, however was forced during the Napoleonic occupation to sell many works of art; his portrait (1794) by Angelica Kauffman is on display in the palace.

In 1958, the marquis Paolo and Franco Spinola donated the building, complete with its furnishings, artworks, silverware, ceramics, etchings and books, to the Italian government.