Among the renovations was in 1848-49, landscape architect, Antonio Caregaro Negrin created a new garden in the romantic style, with two hills and a small bridge, which still exists today.

[6] Initially, two separate colleges were founded in Padua (in 1834) and Venice (in 1836, in Ca' Pesaro) with the contributions of two wealthy Armenian businessmen from Madras, India, Samuel Mkrtich Moorat and Edward Raphael.

[7][8] The Moorat-Raphael College maintained a special prestige among the Armenian diaspora,[6] with notable alumni including: Originally positioned on the third floor arched gable of the façade, the stone coat of arms of the Zenobio family has since been relocated to the internal garden of the palace.

The ballroom and adjacent rooms feature frescoes decorated by Ludovico Dorigny, Gregorio Lazzarini, and a young Giovanni Battista Tiepolo,[13][14] complemented by the stucco work of Abbondio Stazio.

The panels depict mythologic scenes and the life of Queen Zenobia of the 3rd-century Palmyrene Empire, a putative ancestor of the Zenobio family.

Dorigny’s ceiling composition, Allegory of the Dawn (Aurora),[15] features a quadratura framed by pilaster enriched with foliage and animated with male and female figures incarnating the Sciences and the Arts.

[16][17] The Italian film Viaggi di nozze, directed by Carlo Verdone, features a scene in front of the palace where Raniero and the palanquins emerge with the coffin in which Fosca rests.

[18] Several scenes from episodes of the German television series Commissario Brunetti, including "Death in a Strange Country" (2006), "Wilful Behaviour" (2007) and "The Golden Egg" (2016), were filmed at Ca' Zenobio.

[19] In Season 29, Episode 7 of the American reality competition show The Amazing Race, contestants took a water taxi to Ca' Zenobio to find their next clue.