[2] In 1756, the palazzo became a center for the Christian teaching organization, the De La Salle Brothers, which had previously been housed at the Trinità dei Monti.

[3] During the Grand Tour, the palazzo was a visiting spot for artists and scholars like Joshua Reynolds, Johann Joachim Winckelmann, Jacques-Louis David, and painters of the Nazarene movement.

[4] In 2000, the restoration of the palazzo's structure and decoration was undertaken by the architect Enrico Da Gai at the direction of the Max Planck Society, which runs the building's library.

Marie Casimire Louise de La Grange d'Arquien made later modifications, like the Trinità dei Monti facade.

The palazzo is known for the odd decorations on its cornicing and windows, which look like monstrous open mouths inspired by the Gardens of Bomarzo and Mannerist architecture.

The palazzo was initially designed in three parts: a studio on the Piazza Trinità dei Monti, the residence facing via Sistina, and the garden with an entrance from via Gregoriana.